Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review
維生素D對於感染COVID-19以及預後的影響：系統性文獻回顧
維生素D對於包膜病毒具有直接的抗病毒作用，而冠狀病毒就是一種包膜病毒。
2019年的冠狀病毒病死亡率很高，其中嚴重急性呼吸道症候群是主要的死亡原因。而維生素D可以調節對於感染COVID-19的免疫力和氧化反應。
在所審查的九項研究中，七項（77.8％）顯示COVID-19感染，預後和死亡率與維生素D狀況相關。
經審查的文章表明，血液中維生素D的狀況可以確定與「感染COVID-19的風險，COVID-19的嚴重性以及COVID-19導致的死亡率」有關。
因此，建議通過補充或自然方法（例如皮膚曬太陽）保持適當的維生素D水平，以使人能夠應對流行性疾病。
Hiwot Yisak,1 Amien Ewunetei,2 Belayneh Kefale,2 Melkalem Mamuye,1 Fentaw Teshome,1 Birhanie Ambaw,1 Getachew Yideg Yitbarek3
1Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 3Department of Biomedical Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Correspondence: Hiwot Yisak
Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Tel +251-91-372-8949
Email hyisak@yahoo.com
Introduction: Vitamin D status is related to risks of influenza and respiratory tract infections. Vitamin D has direct antiviral effects primarily against enveloped viruses, and coronavirus is an enveloped virus. The 2019 coronavirus disease had a high mortality rate and impacted the whole population of the planet, with severe acute respiratory syndrome the principal cause of death. Vitamin D can adequately modulate and regulate the immune and oxidative response to infection with COVID-19. The goal of this systematic review was thus to summarize and decide if there were a link between vitamin D status and COVID-19 infection and prognosis.
Methods: The protocol of this study is documented in the Prospero database and can be accessed with the protocol number CRD42020201283. PubMed and Google Scholar were used for a literature search from August 2020 to September 2020. We restricted the year of publication of reviewed articles to 2019– 2020, and the selected language was English. Studies that used secondary data, feedback, or analysis of reviews were removed. To assess the standard of studies included, the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method was used.
Results: Of the nine studies reviewed, seven (77.8%) showed that COVID-19 infection, prognosis, and mortality were correlated with vitamin D status.
Conclusion: Most of the articles reviewed showed that blood vitamin D status can determine the risk of being infected with COVID-19, seriousness of COVID-19, and mortality from COVID-19. Therefore, maintaining appropriate levels of Vitamin D through supplementation or natural methods, eg, sunlight on the skin, is recommended for the public to be able to cope with the pandemic.
資料來源: https://tinyurl.com/y289zmub
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